The C4B Antibody (Center) from MyBioSource.com is a Rabbit Polyclonal antibody to C4, C4A, C4A4, C4B, C4S, CH, Complement C4a, Complement C4b, and RG. This antibody recognizes Human, and Mouse antigen. The C4B Antibody (Center) has been validated for the following applications: ELISA, and Western Blot.
Description
This gene encodes the basic form of complement factor 4,
part of the classical activation pathway. The protein is expressed
as a single chain precursor which is proteolytically cleaved into a
trimer of alpha, beta, and gamma chains prior to secretion. The
trimer provides a surface for interaction between the
antigen-antibody complex and other complement components. The alpha
chain may be cleaved to release C4 anaphylatoxin, a mediator of
local inflammation. Deficiency of this protein is associated with
systemic lupus erythematosus. This gene localizes to the major
histocompatibility complex (MHC) class III region on chromosome 6.
Varying haplotypes of this gene cluster exist, such that
individuals may have 1, 2, or 3 copies of this gene. In addition,
this gene exists as a long form and a short form due to the
presence or absence of a 6.4 kb endogenous HERV-K retrovirus in
intron 9